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Atovaquone/Proguanil (Generic Malarone)
Atovaquone/Proguanil (generic Malarone) is a malaria tablet which has a low side effect profile. One tablet needs to be taken every day, starting 2 days before entering the malaria zone, whilst there and for 7 days after leaving.
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Atovaquone/Proguanil Prices
| Medicine | x16 Tablets (1 Week) | x17 Tablets (8 Days) | x18 Tablets (9 Days) | x19 Tablets (10 Days) | x21 Tablets (12 Days) | x23 Tablets (2 Weeks) | x30 Tablets (3 Weeks) | x37 Tablets (4 Weeks) | x51 Tablets (6 Weeks) | x65 Tablets (8 Weeks) | x79 Tablets (10 Weeks) | x93 Tablets (12 Weeks) | x193 Tablets (6 Months) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Atovaquone/Proguanil 250mg/100mg Tablets | £29.50 | £31.35 | £33.20 | £35.05 | £38.75 | £42.45 | £55.40 | £68.35 | £94.25 | £120.15 | £134.18 | £159.38 | £356.95 |
About Atovaquone/Proguanil tablets
Key Points
- Widely used malaria tablets
- Effectively prevents and treats malaria
- Take once a day
- Mild side effects when used as directed
Buy atovaquone/proguanil online
Simply choose the number of days you want malaria cover for, fill out a short and simple questionnaire and checkout. We aim to keep our prices as low as possible and dispatch all orders as soon as possible.
What is atovaquone/proguanil?
Malarone Atovaquone proguanil is one of the most taken and well-known anti-malaria tablets, that is taken by used by millions of people worldwide. It contains the same active ingredients (Atovaquone/Proguanil) as Malarone but is the unbranded version, also known as generic Malarone. Both versions are pharmaceutically the same (i.e. they both contain the same active ingredient), however, generic Malarone is cheaper than the branded version.
How does atovaquone/proguanil work?
It contains two ingredients Atovaquone and Proguanil. When you are bitten by a mosquito that is infected, the malaria parasite enters your blood stream. Atovaquone and Proguanil work together to prevent the malarial parasites from growing, eventually killing them. This way they are unable to replicate and spread inside the human body.
Atovaquone/proguanil dosage instructions
How do you take atovaquone/proguanil?
To prevent malaria:
Take one tablet daily, starting 2 days before you enter the malaria zone. Continue to take one tablet daily for the duration of your stay and for 7 days after. It is very important to continue to take the tablets, even after you have left the malaria zone. This is to ensure that the tablets continue to work to destroy any malarial parasites that may have entered the body.
Take the tablets at the same time every day, preferably with food or a milky drink. This helps ensure the tablet has been absorbed effectively and minimizes stomach-related side-effects from the tablets such as nausea and indigestion.
Please note: You should not stop taking Atovaquone/Proguanil Hydrochloride early without advice because this can put you at risk of getting malaria. Once bitten from an infected mosquito, it takes 7 days to make certain that parasites in your blood are killed.
To treat malaria:
Adults should take 4 tablets once a day for 3 days.
Some types of infection take a long time to cause malaria symptoms. You may not notice symptoms until several days, weeks or even months after returning from abroad. If you begin to feel unwell and have a high temperature, headache, shivering and tiredness after returning home speak to your doctor as soon as possible.
What should I do if I forget to take atovaquone/proguanil?
Take a tablet as soon as you remember, provided it is on the same day you forgot. If you don't remember until the next day, leave the forgotten dose out. Do not take two tablets at the same time or within a close time frame of each other. Resistance is built up after taking the tablets for a while, so missing one dose shouldn't be too much of a problem. It may be a good idea to set a reminder on your phone, to ensure you don't forget.
Atovaquone-proguanil side effects
Atovaquone-proguanil has a low side effect profile which means that when used as directed, it causes relatively few, mild or manageable adverse effects. Side effects reported have been mild and have not lasted very long.
Very common (can affect more than 1 in 10 people):
- Headache
- Nausea and vomiting
- Pain in stomach
- Diarrhoea
Common (can affect up to 1 in 10 people):
- Dizziness
- Insomnia
- Strange dreams
- Depression
- Loss of appetite
- Fever
- Rash, which may be itchy
- Cough
Some of the following common side effects may show in blood tests:
- Decline in red blood cells (anaemia)
- Decline in white blood cells (neutropenia)
- Low levels of sodium in the blood (hyponatraemia)
- Increase in liver enzymes
Severe reactions have been reported in a small number of people. You should stop taking atovaquone/proguanil hydrochloride and contact your GP immediately if you experience any of the following severe allergic reaction symptoms:
- A rash and itchiness
- Wheezing that comes on suddenly, tightness in the chest or throat or difficulty breathing
- Low blood pressure
- Swollen face, eyelids, lips, tongue or other area of the body
- Skin rash, it may blister and have central dark spots, surrounded by paler area with a dark ring around the edge
- Severe widespread rash with blisters and peeling skin, located around the mouth, nose, eyes and genitals
Atovaquone/proguanil warnings
Who should not use atovaquone/proguanil?
You should avoid taking generic Malarone if:
- You are allergic to any of the ingredients contained in the tablet
- You have severe kidney disease
- There are suitable alternatives, and you should speak to your doctor or pharmacist about the other options that can be taken.
Atovaquone/proguanil and pregnancy
Pregnant women are generally advised to avoid travelling to areas where malaria is present, as there is an increased risk of complications arising from malaria to both mother and baby. In situations where travel cannot be avoided, you should speak to your doctor about which antimalarials are suitable to take. This may be dependent on several factors such as the trimester of pregnancy you are in and which antimalarials are proven to be safe for pregnant women.
Atovaquone/proguanil is not considered safe for those pregnant due to limited research. It should only be taken under the advice and care of your doctor, who will consider whether or not the benefits of taking atovaquone/proguanil, outweigh the risks. If you find out that you are pregnant whilst taking Atovaquone/proguanil, you should phone your doctor immediately for advice. If you are trying for a baby, you should delay this until you have finished your prescribed course of antimalarials.
Pregnant women are advised to take extra precautions when travelling to areas where malaria is present.
Atovaquone/proguanil and breastfeeding
Breastfeeding women are advised to avoid taking atovaquone/proguanil, unless your doctor has advised otherwise.
Atovaquone/proguanil interactions
What if I am taking other medication?
The effectiveness of atovaquone/proguanil may be affected by other medication. It may also affect other medications you may be taking, either increasing or decreasing their strength. You should speak to your doctor if you are taking any of the following:
- Metoclopramide, used in the treatment of nausea and vomiting
- Antibiotics including those belonging to the tetracycline class, rifabutin or rifampicin
- Efavirenz or other similar medication used in the treatment of HIV
- Warfarin or other similar medication used to this the blood
- Etoposide, used in the treatment of cancer
You may still be eligible to take atovaquone/proguanil, but your doctor may wish to monitor you.
Can I drink alcohol with atovaquone/proguanil?
Atovaquone/proguanil does not interact with alcohol, and you can drink whilst taking these tablets.
Atovaquone/proguanil alternatives
Atovaquone-proguanil vs Malarone
- Malarone malaria tablets are the branded version of atovaquone/proguanil
- Same active ingredients, atovaquone 250mg and proguanil 100mg
- Work in a similar way to prevent malaria
- Inactive ingredients typically vary
Atovaquone-proguanil vs Doxycycline
- Both can be used for prevention and treatment of malaria
- Doxcycline is commonly used for prevention, especially in areas with multidrug-resistant strains
- Atovaquone/proguanil has a shorter post-travel dosing period (7 days) compared to doxycycline (4 weeks), which might be more convenient for short holidays
- Atovaquone/proguanil has a low side effect profile and typically has fewer side effects
Preference is largely dependent on your health history, how long you will travel for, potential for exposure to sunlight and personal preferences with dosing and side effect tolerability.
Atovaquone/proguanil ingredients
Active ingredients: 250mg atovaquone and 100mg proguanil hydrochloride
Inactive ingredients: Tablet core - cellulose microcrystalline, Povidone (K-30), Crospovidone (Type A), Poloxamer 188, Magnesium stearate. Film-coat - Titanium dioxide (E171), Lactose monohydrate, Macrogol 4000, Hypromellose 15cP (E464), Hypromellose 50cP (E464), Hypromellose 3cP (E464), Iron oxide red (E172), Iron oxide black (E172), Iron oxide yellow (E172)
Sources
British National Formulary. (n.d.). Atovaquone with Proguanil Hydrochloride. Retrieved August 26, 2024, from https://bnf.nice.org.uk/drugs/atovaquone-with-proguanil-hydrochloride/
It is extremely important to continue to take atovaquone/proguanil (generic Malarone) for 7 days after having left the malaria zone. The reason for this is that it takes 7 days of continuous treatment to ensure that any malaria parasites that may be present in your blood from an infected mosquito bite are killed. As a result, parasites are unable to replicate in your body to cause malaria. Stopping tablets early reduces the likeliness of tablets working as a preventative measure.
One of the side-effects of generic Malarone is nausea. Not everybody is affected by this, but some people may be. To reduce this side-effect, it is recommended to take your tablets after a meal. By lining your stomach, you are less likely to feel sick. Generic Malarone should be taken a couple of days before you travel, which should give you an idea of how your body will react to it. If you find yourself feeling extremely nauseas or sick, try taking the tablets with simple carbohydrates such as rice, pasta or potatoes.
If you vomit within one hour of having taken your tablet, take another one. Don't worry about being one tablet short. Just send us an e-mail and we'll have a replacement sent out to you free of charge.
Malarone is reported to be over 90% effective when used together with other preventative measures. As atovaquone/proguanil contains the same ingredients as its branded counterpart, the same applies.
Both atovaquone/proguanil and the branded version Malarone have been used for many years by millions of travellers around the world. It has been proven to be a safe and effective malaria medication and has the mildest side-effect profile in comparison to other anti-malaria tablets.
You should speak to your doctor if:
- You are pregnant or breastfeeding
- You have found out that you are pregnant whilst taking generic Malarone
- You have missed multiple doses
- The tablets are making you extremely sick (your doctor may wish to prescribe you an alternative)
- You are displaying symptoms of allergy after having taken generic Malarone, such as a severe skin rash or blisters, itchiness, difficulty breathing, wheezing, dizziness or swelling in any part of the body. This is very unusual and rare; however, you should seek immediate medical attention if you experience any of these symptoms.
There shouldn’t be a problem taking atovaquone/proguanil onto an aeroplane. It is a good idea to keep the tablets in their original box with the pharmacy labels. It is advised to check with the airline beforehand, as well as the country of travel, to find out if there are any procedures that need to be followed in regard to bringing in medication for personal use.
You can crush atovaquone/proguanil tablets and sprinkle them over your food. We advise placing the tablet in a small plastic bag and crushing it whilst the tablet is inside the bag to avoid wastage. You should then empty the contents of the bag onto your food such as a bowl of sweet yoghurt to mask the bitterness.
You should visit the local pharmacy and find out how you can obtain a replacement. If this is not possible, you can contact us, and we will try our best to help you. If you lose one or two tablets, continue to take your malaria tablets as usual, and we can post you replacement tablets upon your return.
All malaria tablets provide a high rate of protection and reduce the chances of getting malaria; however, no antimalarial drugs can provide 100% protection. If you experience any symptoms of malaria within one year of having returned, you should seek prompt medical advice. Symptoms of malaria include fever, headaches, vomiting, diarrhoea, muscle pain and feeling hot.
Whilst generic Malarone is suitable for children to take, we are unable to prescribe to those under the age of 18. If your partner or a friend would like to buy malaria tablets online, they would need to fill out a medical questionnaire and checkout themselves, using their own account.
Summary For Atovaquone/Proguanil (Generic Malarone)
| Medication Class | Antimalarial |
|---|---|
| Mechanism of action | Stops the growth of malarial parasite, prevents and treats disease |
| Active ingredient | Atovaquone / Proguanil Hydrochloride |
| Strength | 250 mg / 100 mg |
| Effective within | Typically, 2-3 days |
| Dosage Instructions | One tablet taken daily |
| Manufacturer | Mylan, Amarox, Teva |
| Use with alcohol | In moderation |
Product Reviews For Atovaquone/Proguanil (Generic Malarone)
See over 55 product reviews
Product rated 5/5
By Ely Butler, 10th of November
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OTHER OPTIONS INCLUDE
Doxycycline is a cost-effective antimalarial drug. They should be taken 2 days before entering the malaria zone, whilst there and for 28 days after leaving.
Malarone is an antimalarial drug produced by GSK. It contains the active ingredients atovaquone and proguanil and is also available as a generic (non-branded) version. It has a low side effect profile and is well tolerated. It needs to be taken daily, starting 2 days before travel, whilst there and for 7 days after.
Lariam is an antimalarial medication, containing the active ingredient mefloquine. It needs to be taken once a week, starting 1 week before entering the malaria zone, whilst there and for 4 weeks after.
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